Article
Oncogenic activation of the PI3-kinase p110β isoform via the tumor-derived PIK3Cβ(D1067V) kinase domain mutation.
Oncogene - 3 Mar 2016
Pazarentzos E, Giannikopoulos P, Hrustanovic G, St John J, Olivas V R, Gubens M A, Balassanian R, Weissman J, Polkinghorn W, Bivona T G
Abstract excerpt
Activation of the phosphoinositide 3-kinase (PI3K) pathway occurs widely in human cancers. Although somatic mutations in the PI3K pathway genes PIK3CA and PTEN are known to drive PI3K pathway activation and cancer growth, the significance of somatic mutations in other PI3K pathway genes is less clear. Here, we establish the signaling and oncogenic properties of a recurrent somatic mutation in the PI3K p110β...
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