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Article

Systematic Functional Characterization of Resistance to PI3K Inhibition in Breast Cancer

7 Sept 2016

Abstract excerpt

PIK3CA (which encodes the PI3K alpha isoform) is the most frequently mutated oncogene in breast cancer. Small-molecule PI3K inhibitors have shown promise in clinical trials; however, intrinsic and acquired resistance limits their utility. We used a systematic gain-of-function approach to identify genes whose upregulation confers resistance to the PI3K inhibitor BYL719 in breast cancer cells. Among the validated...

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PMID: 27604488
DOI: 10.1158/2159-8290.cd-16-0305

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