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Article

Defining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers

20 Aug 2021

Abstract excerpt

Previous studies have suggested that PTEN loss is associated with p110β signaling dependency, leading to the clinical development of p110β-selective inhibitors. Here we use a panel pre-clinical models to reveal that PI3K isoform dependency is not governed by loss of PTEN and is impacted by feedback inhibition and concurrent PIK3CA/PIK3CB alterations. Furthermore, while pan-PI3K inhibition in PTEN-deficient tumors...

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Share to PI3K/AKT/mTOR signaling in cancer
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PMID: 34417459
DOI: 10.1038/s41467-021-25341-9

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