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Article

Analysis of a four generation family reveals the widespread sequence-dependent maintenance of allelic DNA methylation in somatic and germ cells.

Scientific reports - 13 Jan 2016

Tang Aifa, Huang Yi, Li Zesong, Wan Shengqing, Mou Lisha, Yin Guangliang, Li Ning, Xie Jun, Xia Yudong, Li Xianxin, Luo Liya, Zhang Junwen, Chen Shen, Wu Song, Sun Jihua, Sun Xiaojuan, Jiang Zhimao, Chen Jing, Li Yingrui, Wang Jian, Wang Jun, Cai Zhiming, Gui Yaoting

Abstract excerpt

Differential methylation of the homologous chromosomes, a well-known mechanism leading to genomic imprinting and X-chromosome inactivation, is widely reported at the non-imprinted regions on autosomes. To evaluate the transgenerational DNA methylation patterns in human, we analyzed the DNA methylomes of somatic and germ cells in a four-generation family. We found that allelic asymmetry of DNA methylation was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26758766
DOI: 10.1038/srep19260
PMCID: PMC4713049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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