Article
Non-imprinted allele-specific DNA methylation on human autosomes.
Genome biology - 1 Jan 2009
Zhang Yingying, Rohde Christian, Reinhardt Richard, Voelcker-Rehage Claudia, Jeltsch Albert
Abstract excerpt
BACKGROUND: Differential DNA methylation between alleles is well established in imprinted genes and the X chromosomes in females but has rarely been reported at non-imprinted loci on autosomes. RESULTS: We studied DNA methylation of cytosine-guanine dinucleotide (CpG) islands on chromosome 21 in leukocytes from several healthy individuals and observed novel cases of pronounced differential methylation of alleles....
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