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Article

Hypermethylation of the non-imprinted maternal MEG3 and paternal MEST alleles is highly variable among normal individuals.

PloS one - 1 Jan 2017

Haertle Larissa, Maierhofer Anna, Böck Julia, Lehnen Harald, Böttcher Yvonne, Blüher Matthias, Schorsch Martin, Potabattula Ramya, El Hajj Nady, Appenzeller Silke, Haaf Thomas

Abstract excerpt

Imprinted genes show parent-specific activity (functional haploidy), which makes them particularly vulnerable to epigenetic dysregulation. Here we studied the methylation profiles of oppositely imprinted genes at single DNA molecule resolution by two independent parental allele-specific deep bisulfite sequencing (DBS) techniques. Using Roche (GSJunior) next generation sequencing technology, we analyzed the...

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Share to DNA Methylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28854270
DOI: 10.1371/journal.pone.0184030
PMCID: PMC5576652

Genes

MEST
PEG3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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