Atlas of imprinted and allele-specific DNA methylation in the human body.

Abstract excerpt

Allele-specific DNA methylation reflects genetic variation and parentally-inherited changes, and is involved in gene regulation and pathologies. Yet, our knowledge of this phenomenon is largely limited to blood. Here we present a comprehensive atlas of allele-specific DNA methylation using deep whole-genome sequencing across 39 normal human cell types. We identified 325k regions, covering 6% of the genome and 11%...

Topics

• Humans
• DNA Methylation
• Genomic Imprinting
• Alleles
• CpG Islands
• Genome, Human
• Female