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Article

Analysis of DNA methylation in a three-generation family reveals widespread genetic influence on epigenetic regulation.

PLoS genetics - 1 Aug 2011

Gertz Jason, Varley Katherine E, Reddy Timothy E, Bowling Kevin M, Pauli Florencia, Parker Stephanie L, Kucera Katerina S, Willard Huntington F, Myers Richard M

Abstract excerpt

The methylation of cytosines in CpG dinucleotides is essential for cellular differentiation and the progression of many cancers, and it plays an important role in gametic imprinting. To assess variation and inheritance of genome-wide patterns of DNA methylation simultaneously in humans, we applied reduced representation bisulfite sequencing (RRBS) to somatic DNA from six members of a three-generation family. We...

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Chromosomes, Human, Pair 21
Chromosomes, Human, Pair 8
Chromosomes, Human, X
CpG Islands
DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Epigenesis, Genetic

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PMID: 21852959
DOI: 10.1371/journal.pgen.1002228
PMCID: PMC3154961

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