Article
Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration.
Science signaling - 27 Jul 2021
Liu Qinfang, Bautista-Gomez Judith, Higgins Daniel A, Yu Jianzhong, Xiong Yulan
Abstract excerpt
Mutations in the kinase LRRK2 and impaired endocytic trafficking are both implicated in the pathogenesis of Parkinson's disease (PD). Expression of the PD-associated LRRK2 mutant in mouse dopaminergic neurons was shown to disrupt clathrin-mediated endocytic trafficking. Here, we explored the molecular mechanism linking LRRK2 to endocytosis and found that LRRK2 bound to and phosphorylated the μ2 subunit of the...
Topics
- Animals
- Dopamine
- Dopaminergic Neurons
- Endocytosis
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mice
- Mutation
- Phosphorylation