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ERK1 and ERK2 Regulate Chondrocyte Terminal Differentiation During Endochondral Bone Formation

17 Nov 2014

Abstract excerpt

Chondrocytes in the epiphyseal cartilage undergo terminal differentiation prior to their removal through apoptosis. To examine the role of ERK1 and ERK2 in chondrocyte terminal differentiation, we generated Osterix (Osx)-Cre; ERK1(-/-) ; ERK2(flox/flox) mice (conditional knockout Osx [cKOosx]), in which ERK1 and ERK2 were deleted in hypertrophic chondrocytes. These cKOosx mice were grossly normal in size at...

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PMID: 25401279
DOI: 10.1002/jbmr.2409

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