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Article

Saccharomyces cerevisiae mutants defective in chromosome segregation.

Yeast (Chichester, England) - 1 Jan 2000

McGrew J T, Xiao Z X, Fitzgerald-Hayes M

Abstract excerpt

We have devised a genetic screen to identify trans-acting factors involved in chromosome transmission in yeast. This approach was designed to potentially identify a subset of genes encoding proteins that interact with centromere DNA. It has been shown that mutations in yeast centromere DNA cause aberrant chromosome segregation during mitosis and meiosis. We reasoned that the function of an altered centromere...

Topics

Base Sequence
Centromere
Chromosomes
Cloning, Molecular
DNA Mutational Analysis
DNA, Fungal
Genes, Fungal
Mitosis
Molecular Sequence Data
Phenotype
Plasmids
Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Homology, Nucleic Acid

Source

Identifiers

PMID: 2675488
DOI: 10.1002/yea.320050407

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2675488-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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