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Article

In vivo analysis of the Saccharomyces cerevisiae centromere CDEIII sequence: requirements for mitotic chromosome segregation.

Molecular and cellular biology - 1 Oct 1991

Jehn B, Niedenthal R, Hegemann J H

Abstract excerpt

In the yeast Saccharomyces cerevisiae, the complete information needed in cis to specify a fully functional mitotic and meiotic centromere is contained within 120 bp arranged in the three conserved centromeric (CEN) DNA elements CDEI, -II, and -III. The 25-bp CDEIII is most important for faithful chromosome segregation. We have constructed single- and double-base substitutions in all highly conserved residues and...

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Identifiers

PMID: 1922041
DOI: 10.1128/mcb.11.10.5212-5221.1991
PMCID: PMC361563

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