Article
Ultra-Deep Bisulfite Sequencing to Detect Specific DNA Methylation Patterns of Minor Cell Types in Heterogeneous Cell Populations: An Example of the Pituitary Tissue.
PloS one - 1 Jan 2016
Arai Yoshikazu, Fukukawa Hisho, Atozi Takanori, Matsumoto Shoma, Hanazono Yutaka, Nagashima Hiroshi, Ohgane Jun
Abstract excerpt
DNA methylation is an epigenetic modification important for cell fate determination and cell type-specific gene expression. Transcriptional regulatory regions of the mammalian genome contain a large number of tissue/cell type-dependent differentially methylated regions (T-DMRs) with DNA methylation patterns crucial for transcription of the corresponding genes. In general, tissues consist of multiple cell types in...
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