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Comparative whole genome DNA methylation profiling of cattle sperm and somatic tissues reveals striking hypomethylated patterns in sperm

9 Apr 2018

Abstract excerpt

Background: Although sperm DNA methylation has been studied in humans and other species, its status in cattle is largely unknown. Results: Using whole-genome bisulfite sequencing (WGBS), we profiled the DNA methylome of cattle sperm through comparison with three somatic tissues (mammary gland, brain, and blood). Large differences between cattle sperm and somatic cells were observed in the methylation patterns of...

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PMID: 29635292
DOI: 10.1093/gigascience/giy039

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