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Article

Multiomics analysis of narcolepsy T cells: global hypomethylation linked to T cell proliferation

2024-05-04

Abstract excerpt

<h4>Summary</h4> Narcolepsy type 1 (NT1) is a chronic sleep disorder caused by a loss of orexin-producing cells in the brain and involves autoimmune mechanisms, including the presence of autoreactive T cells. We performed a genome-wide DNA methylation analysis using CD4 + and CD8 + T cells of NT1 patients. Analysis of differentially methylated regions as well as multiomics analysis with genomic and transcriptom...

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Literature Corpus work
e378584e-ae49-55f9-a20d-3c0dc9e765e2
DOI
10.1101/2024.05.01.592019
Open publication

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