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Article

Oral Morphine Pharmacokinetic in Obesity: The Role of P-Glycoprotein, MRP2, MRP3, UGT2B7, and CYP3A4 Jejunal Contents and Obesity-Associated Biomarkers.

Molecular pharmaceutics - 7 Mar 2016

Lloret-Linares Célia, Miyauchi Eisuke, Luo Huilong, Labat Laurence, Bouillot Jean-Luc, Poitou Christine, Oppert Jean-Michel, Laplanche Jean-Louis, Mouly Stéphane, Scherrmann Jean-Michel, Uchida Yasuo, Tachikawa Masanori, Terasaki Tetsuya, Bergmann Jean-François, Declèves Xavier

Abstract excerpt

The objective of our work was to study the association between the jejunal expression levels of P-gp, MRP2, MRP3, UGT2B7, CYP3A4, the ABCB1 c.3435C > T polymorphism, and several obesity-associated biomarkers, as well as oral morphine and glucuronides pharmacokinetics in a population of morbidly obese subjects. The pharmacokinetics of oral morphine (30 mg) and its glucuronides was performed in obese patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26751618
DOI: 10.1021/acs.molpharmaceut.5b00656

Genes

ABCB1

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