Article
Effects of Obesity and Leptin Deficiency on Morphine Pharmacokinetics in a Mouse Model.
Anesthesia and analgesia - 1 Dec 2016
Dalesio Nicholas M, Hendrix Craig W, McMichael Douglas Hale, Thompson Carol B, Lee Carlton K K, Pho Huy, Arias Rafael S, Lynn Rachael Rzasa, Galinkin Jeffrey, Yaster Myron, Brown Robert H, Schwartz Alan R
Abstract excerpt
BACKGROUND: Obesity causes multiorgan dysfunction, specifically metabolic abnormalities in the liver. Obese patients are opioid-sensitive and have high rates of respiratory complications after surgery. Obesity also has been shown to cause resistance to leptin, an adipose-derived hormone that is key in regulating hunger, metabolism, and respiratory stimulation. We hypothesized that obesity and leptin deficiency...
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