Article
Population pharmacokinetics of omeprazole in obese and normal-weight adults.
Expert review of clinical pharmacology - 1 Apr 2022
Chen Kaifeng, Luo Ping, Yang Guoping, Zhu Shaihong, Deng Chenhui, Ding Junjie, Lin Yaqi, Zhu Liyong, Pei Qi
Abstract excerpt
BACKGROUND: Obesity is related to many pathophysiological changes that may result in altered drug disposition. Omeprazole is the most common option utilized for acid-related disorders ; however, the pharmacokinetic (PK) and dosing recommendations for the obese patient population are lacking. METHODS: Data from 40 healthy subjects with normal weights and data from 61 obese subjects were included. The subjects all...
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