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Article

A novel mechanism of Smads/miR‐675/TGFβR1 axis modulating the proliferation and remodeling of mouse cardiac fibroblasts

5 Apr 2019

Abstract excerpt

Cardiac fibroblasts (CFs) can over-proliferate during the progression of cardiac fibrosis, accompanied by a net accumulation of extracellular matrix proteins. Based on the profibrotic actions of transforming growth factor beta 1 (TGFβ1), investigating the mechanisms of TGFβ1 function in CFs may provide new directions to treatment for cardiac fibrosis. microRNAs (miRNAs) could control CFs proliferation or...

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PMID: 30953355
DOI: 10.1002/jcp.28628

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