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Article

Multifaceted TGF‐β signaling, a master regulator: From bench‐to‐bedside, intricacies, and complexities

19 Oct 2023

Abstract excerpt

Physiological embryogenesis and adult tissue homeostasis are regulated by transforming growth factor-β (TGF-β), an evolutionarily conserved family of secreted polypeptide factors, acting in an autocrine and paracrine manner. The role of TGF-β in inflammation, fibrosis, and cancer is complex and sometimes even contradictory, exhibiting either inhibitory or promoting effects depending on the stage of the disease....

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PMID: 37859532
DOI: 10.1002/cbin.12097

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