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Article

Factor XIII A-Subunit V34L Variant Affects Thrombus Cross-Linking in a Murine Model of Thrombosis.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2016

Duval Cédric, Ali Majid, Chaudhry Waleed W, Ridger Victoria C, Ariëns Robert A S, Philippou Helen

Abstract excerpt

OBJECTIVE: Factor XIII (FXIII) cross-links fibrin upon activation by thrombin. Activation involves cleavage at residue 37 by thrombin, releasing an activation peptide. A common polymorphism (valine to leucine variant at residue 34, V34L), located in the activation peptide, has been associated with increased activation rates and paradoxically a protective effect in cardiovascular disease. There is, currently, no...

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PMID: 26743168
DOI: 10.1161/ATVBAHA.115.306695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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