Article
Joint linkage and association of six single-nucleotide polymorphisms in the factor XIII-A subunit gene point to V34L as the main functional locus.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2006
de Lange Marlies, Andrew Toby, Snieder Harold, Ge Dongliang, Futers T Simon, Standeven Kristina, Spector Tim D, Grant Peter J, Ariëns Robert A S
Abstract excerpt
OBJECTIVE: Activated factor XIII (FXIII) crosslinks fibrin to enhance the mechanical strength of a blood clot and increase its resistance to fibrinolysis. The prevalence of a common variant in the FXIII-A gene (V34L) has been reported to be lower in patients with myocardial infarction and ischemic stroke than in controls, suggesting a protective role for this polymorphism in vascular diseases. The current study...
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