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Article

Effect of Val34Leu polymorphism on the activation of the coagulation factor XIII-A.

Thrombosis and haemostasis - 1 Oct 2000

Wartiovaara U, Mikkola H, Szôke G, Haramura G, Kárpáti L, Balogh I, Lassila R, Muszbek L, Palotie A

Abstract excerpt

Coagulation factor XIII (FXIII) is a protransglutaminase involved in the last step of the coagulation cascade by stabilising the fibrin clot. Recently, a common variation (FXIII Val34Leu) has been associated with a decreased risk of myocardial infarction and deep venous thrombosis. Val34Leu is critically located near the thrombin activation site of FXIII-A. In this study we investigated its effects on the...

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PMID: 11057856

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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