Article
The Sensitive Detection of Telomerase Reverse Transcriptase Promoter Mutation by Amplification Refractory Mutation System-PCR.
Genetic testing and molecular biomarkers - 1 Feb 2016
Liu Jinbo, Zhao Zhihua, Sun Miaomiao, Chen Kuisheng, Yuan Weitang, Jiang Guozhong
Abstract excerpt
AIM: In gliomas, mutations in the core promoter region of the telomerase reverse transcriptase (TERT) gene have been associated with specific subtypes and are inversely correlated with IDH1 mutation status, predicting poor prognosis. Thus, TERT promoter mutation status might be a candidate for development as a prognostic biomarker. However, current IDH1 mutation detection methods using conventional polymerase...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.