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Article

TERT promoter mutations lead to high transcriptional activity under hypoxia and temozolomide treatment and predict poor prognosis in gliomas.

PloS one - 1 Jan 2014

Chen Chen, Han Sheng, Meng Lingxuan, Li Zhonghua, Zhang Xue, Wu Anhua

Abstract excerpt

OBJECTIVE: This study explored the effects of telomerase reverse transcriptase (TERT) promoter mutations on transcriptional activity of the TERT gene under hypoxic and temozolomide (TMZ) treatment conditions, and investigated the status and prognostic value of these mutations in gliomas. METHODS: The effect of TERT promoter mutations on the transcriptional activity of the TERT gene under hypoxic and TMZ treatment...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24937153
DOI: 10.1371/journal.pone.0100297
PMCID: PMC4061075

Genes

TERT

Provenance

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