Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of TERT Promoter Mutations Using Targeted Next-Generation Sequencing: Overcoming GC Bias through Trial and Error.

Cancer research and treatment - 1 Jan 2022

Lee Hyunwoo, Lee Boram, Kim Deok Geun, Cho Yoon Ah, Kim Jung-Sun, Suh Yeon-Lim

Abstract excerpt

PURPOSE: Detection of telomerase reverse transcriptase (TERT) promoter mutations is a crucial process in the integrated diagnosis of glioblastomas. However, the TERT promoter region is difficult to amplify because of its high guanine-cytosine (GC) content (> 80%). This study aimed to analyze the capturing of TERT mutations by targeted next-generation sequencing (NGS) using formalin-fixed paraffin-embedded...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brain Neoplasms

Share to Glioblastoma

Share to High-Throughput Nucleotide Sequencing

Share to Promoter Regions, Genetic

Share to Telomerase

Source

Open in PubMed Open full text

Identifiers

PMID: 33940787
DOI: 10.4143/crt.2021.107
PMCID: PMC8756133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of TERT Promoter Mutations Using Targeted Next-Generation Sequencing: Overcoming GC Bias through Trial and Error.PMID 33940787Read ↗

Establishment and Validation of the Detection of TERT Promoter Mutations by Human Gliomas U251 Cell Lines.Semantic proximity Read ↗

The Sensitive Detection of Telomerase Reverse Transcriptase Promoter Mutation by Amplification Refractory Mutation System-PCR.Semantic proximity Read ↗

A tailored next‐generation sequencing panel identified distinct subtypes of wildtype IDH and TERT promoter glioblastomasSemantic proximity Read ↗

Direct comparison of the next-generation sequencing and iTERT PCR methods for the diagnosis of TERT hotspot mutations in advanced solid cancers.Semantic proximity Read ↗

Clinical Application of Comprehensive Genomic Profiling Tests for Diffuse GliomasSemantic proximity Read ↗

Paradoxical prognostic impact of TERT promoter mutations in gliomas depends on different histological and genetic backgrounds.Semantic proximity Read ↗

Detection of TERT Promoter Mutations as a Prognostic Biomarker in Gliomas: Methodology, Prospects, and AdvancesSemantic proximity Read ↗

Genetic mutation patterns among glioblastoma patients in the Taiwanese population - insights from a single institution retrospective study.Semantic proximity Read ↗

Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation.Semantic proximity Read ↗

The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma.Semantic proximity Read ↗

Diagnostic implications of TERT promoter mutation status in diffuse gliomas in a routine clinical setting.Semantic proximity Read ↗

TERTmonitor-qPCR Detection of TERTp Mutations in Glioma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.