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Article

Microbiota-induced obesity requires farnesoid X receptor.

Gut - 1 Mar 2017

Parséus Ava, Sommer Nina, Sommer Felix, Caesar Robert, Molinaro Antonio, Ståhlman Marcus, Greiner Thomas U, Perkins Rosie, Bäckhed Fredrik

Abstract excerpt

OBJECTIVE: The gut microbiota has been implicated as an environmental factor that modulates obesity, and recent evidence suggests that microbiota-mediated changes in bile acid profiles and signalling through the bile acid nuclear receptor farnesoid X receptor (FXR) contribute to impaired host metabolism. Here we investigated if the gut microbiota modulates obesity and associated phenotypes through FXR. DESIGN: We...

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Identifiers

PMID: 26740296
DOI: 10.1136/gutjnl-2015-310283
PMCID: PMC5534765

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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