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Article

Bile acid is a significant host factor shaping the gut microbiome of diet-induced obese mice

1 Dec 2017

Abstract excerpt

BACKGROUND: Intestinal bacteria are known to regulate bile acid (BA) homeostasis via intestinal biotransformation of BAs and stimulation of the expression of fibroblast growth factor 19 through intestinal nuclear farnesoid X receptor (FXR). On the other hand, BAs directly regulate the gut microbiota with their strong antimicrobial activities. It remains unclear, however, how mammalian BAs cross-talk with gut...

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PMID: 29241453
DOI: 10.1186/s12915-017-0462-7

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