Article
Gnotobiotic mice housing conditions critically influence the phenotype associated with transfer of faecal microbiota in a context of obesity.
Gut - 1 May 2023
Daoust Laurence, Choi Béatrice S-Y, Agrinier Anne-Laure, Varin Thibault V, Ouellette Adia, Mitchell Patricia L, Samson Nolwenn, Pilon Genevieve, Levy Emile, Desjardins Yves, Laplante Mathieu, Anhê Fernando F, Houde Vanessa P, Marette Andre
Abstract excerpt
OBJECTIVE: Faecal microbiota transplantation (FMT) in germ-free (GF) mice is a common approach to study the causal role of the gut microbiota in metabolic diseases. Lack of consideration of housing conditions post-FMT may contribute to study heterogeneity. We compared the impact of two housing strategies on the metabolic outcomes of GF mice colonised by gut microbiota from mice treated with a known gut modulator...
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