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Article

Hepatic inflammation caused by dysregulated bile acid synthesis is reversible by butyrate supplementation.

The Journal of pathology - 1 Dec 2017

Sheng Lili, Jena Prasant Kumar, Hu Ying, Liu Hui-Xin, Nagar Nidhi, Kalanetra Karen M, French Samuel William, French Samuel Wheeler, Mills David A, Wan Yu-Jui Yvonne

Abstract excerpt

Dysregulated bile acid (BA) synthesis or reduced farnesoid X receptor (FXR) levels are found in patients having metabolic diseases, autoimmune hepatitis, and liver cirrhosis or cancer. The objective of this study was to establish the relationship between butyrate and dysregulated BA synthesis-induced hepatitis as well as the effect of butyrate in reversing the liver pathology. Wild-type (WT) and FXR knockout (KO)...

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Source

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Identifiers

PMID: 28892150
DOI: 10.1002/path.4983
PMCID: PMC5953422

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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