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Article

Cross-talk between bile acids and intestinal microbiota in host metabolism and health

13 May 2015

Abstract excerpt

Bile acid (BA) is de novo synthesized exclusively in the liver and has direct or indirect antimicrobial effects. On the other hand, the composition and size of the BA pool can be altered by intestinal microbiota via the biotransformation of primary BAs to secondary BAs, and subsequently regulate the nuclear farnesoid X receptor (FXR; NR1H4). The BA-activated FXR plays important roles in BA synthesis and...

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PMID: 26055905
DOI: 10.1631/jzus.b1400327

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