Article

Pregnane X receptor exacerbates nonalcoholic fatty liver disease accompanied by obesity- and inflammation-prone gut microbiome signature

2021-01-26

Abstract excerpt

<title>Abstract</title> <p>Pregnane X receptor (PXR) is a drug receptor with novel functions in promoting non-alcoholic fatty liver disease (NAFLD). We hypothesize that PXR worsens NAFLD accompanied by gut dysbiosis. Wild-type and PXR-knockout mice were fed control or high fat diet (HFD) for 16-weeks. Serum parameters, liver histopathology, transcriptomic profiling, 16S-rDNA sequencing, and bile acid (BA) metabol...

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Literature Corpus work: 9543991d-eaec-5e1e-9b8e-22fd9d176068
DOI: 10.21203/rs.3.rs-134429/v1

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