Article
Genetic polymorphisms of the drug-metabolizing enzyme cytochrome P450 3A5 in a Uyghur Chinese population.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Sept 2016
Chen Zhengshuai, Li Jingjie, Chen Peng, Wang Fengjiao, Zhang Ning, Yang Min, Jin Tianbo, Chen Chao
Abstract excerpt
1. Detection of CYP3A5 variant alleles, and knowledge about their allelic frequency in Uyghur ethnic groups, is important to establish the clinical relevance of screening for these polymorphisms to optimize pharmacotherapy. 2. We used DNA sequencing to investigate the promoter, exons and surrounding introns, and 3'-untranslated region of the CYP3A5 gene in 96 unrelated healthy Uyghur individuals. We also used...
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