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Evaluation of genetic polymorphism of CYP3A5 in normal healthy participants from western India - A cross-sectional study.

Indian journal of pharmacology - 1 Jan 2000

Maurya Miteshkumar Rajaram, Gautam Sunanda, Raj Jeffrey Pradeep, Saha Shruti, Ambre Sanchita, Thakurdesai Aishwarya, Shah Aditya, Thatte Urmila Mukund

Abstract excerpt

BACKGROUND: CYP3A5 enzymes belong to the phase I Group of drug-metabolizing enzymes, which are involved in the metabolism of 50% of the drugs. Participants with CYP3A5 genotype: CYP3A5 *1/*1 are fast metabolizers of drugs and hence will require higher dosing. Whereas those with CYP3A5 * 3/*3 are poor metabolizers of drugs and will require a lower dose to achieve target drug concentration in the blood and those...

Topics

Adolescent
Adult
Cross-Sectional Studies
Cytochrome P-450 CYP3A
Genotype
Healthy Volunteers
Humans
Immunosuppressive Agents
India
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Young Adult

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Open in PubMed Open full text

Identifiers

PMID: 35546460
DOI: 10.4103/ijp.ijp_279_21
PMCID: PMC9249149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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