Article
Genetic polymorphism analysis of the drug-metabolizing enzyme CYP1A2 in a Uyghur Chinese population: a pilot study.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Jan 2016
Geng Tingting, Zhang Xi Yang, Wang Li, Wang Huijuan, Shi Xugang, Kang Longli, Hou Peng, Jin Tianbo
Abstract excerpt
1. CYP1A2 is a highly polymorphic gene and CYP1A2 enzyme results in broad inter-individual variability in response to certain pharmacotherapies, while little is known about the genetic variation of CYP1A2 in Uyghur Chinese population. The aim of the present study was to screen Uyghur volunteers for CYP1A2 genetic polymorphisms. 2. We used DNA sequencing to investigate promoter, exons, introns, and 3' UTR of the...
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