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Article

Creation of chimeric human/rabbit APOBEC1 with HIV-1 restriction and DNA mutation activities.

Scientific reports - 7 Jan 2016

Ikeda Terumasa, Ong Eugene Boon Beng, Watanabe Nobumoto, Sakaguchi Nobuo, Maeda Kazuhiko, Koito Atsushi

Abstract excerpt

APOBEC1 (A1) proteins from lagomorphs and rodents have deaminase-dependent restriction activity against HIV-1, whereas human A1 exerts a negligible effect. To investigate these differences in the restriction of HIV-1 by A1 proteins, a series of chimeric proteins combining rabbit and human A1s was constructed. Homology models of the A1s indicated that their activities derive from functional domains that likely act...

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Source

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Identifiers

PMID: 26738439
DOI: 10.1038/srep19035
PMCID: PMC4704027

Genes

APOBEC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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