Article
Cellular HIV-1 inhibition by truncated old world primate APOBEC3A proteins lacking a complete deaminase domain.
Virology - 1 Nov 2014
Katuwal Miki, Wang Yaqiong, Schmitt Kimberly, Guo Kejun, Halemano Kalani, Santiago Mario L, Stephens Edward B
Abstract excerpt
The APOBEC3 (A3) deaminases are retrovirus restriction factors that were proposed as inhibitory components of HIV-1 gene therapy vectors. However, A3 mutational activity may induce undesired genomic damage and enable HIV-1 to evade drugs and immune responses. Here, we show that A3A protein from Colobus guereza (colA3A) can restrict HIV-1 replication in producer cells in a deaminase-independent manner without...
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