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Mutant p53: One, No One, and One Hundred Thousand

21 Dec 2015

Abstract excerpt

Encoded by the mutated variants of the TP53 tumor suppressor gene, mutant p53 proteins are getting an increased experimental support as active oncoproteins promoting tumor growth and metastasis. p53 missense mutant proteins are losing their wild-type tumor suppressor activity and acquire oncogenic potential, possessing diverse transforming abilities in cell and mouse models. Whether various mutant p53s differ in...

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PMID: 26734571
DOI: 10.3389/fonc.2015.00289

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