A mutation in Dbf4 motif M impairs interactions with DNA replication factors and confers increased resistance to genotoxic agents.

doi:10.1128/MCB.25.17.7494-7504.2005

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Article

A mutation in Dbf4 motif M impairs interactions with DNA replication factors and confers increased resistance to genotoxic agents.

Molecular and cellular biology - 1 Sept 2005

Varrin Angela E, Prasad Ajai A, Scholz Rolf-Peter, Ramer Matthew D, Duncker Bernard P

Abstract excerpt

Dbf4/Cdc7 is required for DNA replication in Saccharomyces cerevisiae and appears to be a target in the S-phase checkpoint. Previously, a 186-amino-acid Dbf4 region that mediates interactions with both the origin recognition complex and Rad53 was identified. We now show this domain also mediates the association between Dbf4 and Mcm2, a key Dbf4/Cdc7 phosphorylation target. Two conserved sequences, the N and M...

Topics

Cell Cycle Proteins
Chromosomal Proteins, Non-Histone
DNA Replication
DNA, Fungal
DNA-Binding Proteins
Drug Resistance, Fungal
Fungal Proteins
Hydroxyurea
Methyl Methanesulfonate
Mutagens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Origin Recognition Complex

Protein Binding

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Two-Hybrid System Techniques

Source

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Identifiers

PMID: 16107698
DOI: 10.1128/MCB.25.17.7494-7504.2005
PMCID: PMC1190303

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A mutation in Dbf4 motif M impairs interactions with DNA replication factors and confers increased resistance to genotoxic agents.PMID 16107698Read ↗

A Dbf4 mutant contributes to bypassing the Rad53-mediated block of origins of replication in response to genotoxic stress.Semantic proximity Read ↗

Dbf4 and Cdc7 proteins promote DNA replication through interactions with distinct Mcm2-7 protein subunits.Semantic proximity Read ↗

Concerted activities of Mcm4, Sld3, and Dbf4 in control of origin activation and DNA replication fork progression.Semantic proximity Read ↗

A conserved domain of Schizosaccharomyces pombe dfp1(+) is uniquely required for chromosome stability following alkylation damage during S phase.Semantic proximity Read ↗

Cdc7 kinases (DDKs) and checkpoint responses: lessons from two yeasts.Semantic proximity Read ↗

The unstructured C-terminal tail of yeast Dpb11 (human TopBP1) protein is dispensable for DNA replication and the S phase checkpoint but required for the G2/M checkpoint.Semantic proximity Read ↗

Structural changes in Mcm5 protein bypass Cdc7-Dbf4 function and reduce replication origin efficiency in Saccharomyces cerevisiae.Semantic proximity Read ↗

DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forksSemantic proximity Read ↗

DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae.Semantic proximity Read ↗

Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression.Semantic proximity Read ↗

Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction.Semantic proximity Read ↗

Novel role for checkpoint Rad53 protein kinase in the initiation of chromosomal DNA replication in Saccharomyces cerevisiae.Semantic proximity Read ↗

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