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Article

A mutation in Dbf4 motif M impairs interactions with DNA replication factors and confers increased resistance to genotoxic agents.

Molecular and cellular biology - 1 Sept 2005

Varrin Angela E, Prasad Ajai A, Scholz Rolf-Peter, Ramer Matthew D, Duncker Bernard P

Abstract excerpt

Dbf4/Cdc7 is required for DNA replication in Saccharomyces cerevisiae and appears to be a target in the S-phase checkpoint. Previously, a 186-amino-acid Dbf4 region that mediates interactions with both the origin recognition complex and Rad53 was identified. We now show this domain also mediates the association between Dbf4 and Mcm2, a key Dbf4/Cdc7 phosphorylation target. Two conserved sequences, the N and M...

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Identifiers

PMID: 16107698
DOI: 10.1128/MCB.25.17.7494-7504.2005
PMCID: PMC1190303

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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A mutation in Dbf4 motif M impairs interactions with DNA replication factors and confers increased resistance to genotoxic agents.PMID 16107698Read ↗

A Dbf4 mutant contributes to bypassing the Rad53-mediated block of origins of replication in response to genotoxic stress.Semantic proximity Read ↗

Dbf4 and Cdc7 proteins promote DNA replication through interactions with distinct Mcm2-7 protein subunits.Semantic proximity Read ↗

Concerted activities of Mcm4, Sld3, and Dbf4 in control of origin activation and DNA replication fork progression.Semantic proximity Read ↗

A conserved domain of Schizosaccharomyces pombe dfp1(+) is uniquely required for chromosome stability following alkylation damage during S phase.Semantic proximity Read ↗

Cdc7 kinases (DDKs) and checkpoint responses: lessons from two yeasts.Semantic proximity Read ↗

The unstructured C-terminal tail of yeast Dpb11 (human TopBP1) protein is dispensable for DNA replication and the S phase checkpoint but required for the G2/M checkpoint.Semantic proximity Read ↗

Structural changes in Mcm5 protein bypass Cdc7-Dbf4 function and reduce replication origin efficiency in Saccharomyces cerevisiae.Semantic proximity Read ↗

DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forksSemantic proximity Read ↗

DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae.Semantic proximity Read ↗

Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression.Semantic proximity Read ↗

Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction.Semantic proximity Read ↗

Novel role for checkpoint Rad53 protein kinase in the initiation of chromosomal DNA replication in Saccharomyces cerevisiae.Semantic proximity Read ↗

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