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Article

A Dbf4 mutant contributes to bypassing the Rad53-mediated block of origins of replication in response to genotoxic stress.

The Journal of biological chemistry - 28 Jan 2011

Duch Alba, Palou Gloria, Jonsson Zophonias O, Palou Roger, Calvo Enrique, Wohlschlegel James, Quintana David G

Abstract excerpt

An intra-S phase checkpoint slows the rate of DNA replication in response to DNA damage and replication fork blocks in eukaryotic cells. In the budding yeast Saccharomyces cerevisiae, such down-regulation is achieved through the Rad53 kinase-dependent block of origins of replication. We have identified the Rad53 phosphorylation sites on Dbf4, the activator subunit of the essential S phase Dbf4-dependent kinase,...

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Identifiers

PMID: 21098477
DOI: 10.1074/jbc.M110.190843
PMCID: PMC3024743

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Dbf4 mutant contributes to bypassing the Rad53-mediated block of origins of replication in response to genotoxic stress.PMID 21098477Read ↗

A mutation in Dbf4 motif M impairs interactions with DNA replication factors and confers increased resistance to genotoxic agents.Semantic proximity Read ↗

Concerted activities of Mcm4, Sld3, and Dbf4 in control of origin activation and DNA replication fork progression.Semantic proximity Read ↗

Cdc7 kinases (DDKs) and checkpoint responses: lessons from two yeasts.Semantic proximity Read ↗

RAD53 regulates DBF4 independently of checkpoint function in Saccharomyces cerevisiae.Semantic proximity Read ↗

Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms.Semantic proximity Read ↗

Fission yeast Hsk1 (Cdc7) kinase is required after replication initiation for induced mutagenesis and proper response to DNA alkylation damage.Semantic proximity Read ↗

Structural changes in Mcm5 protein bypass Cdc7-Dbf4 function and reduce replication origin efficiency in Saccharomyces cerevisiae.Semantic proximity Read ↗

Novel role for checkpoint Rad53 protein kinase in the initiation of chromosomal DNA replication in Saccharomyces cerevisiae.Semantic proximity Read ↗

DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forksSemantic proximity Read ↗

Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis.Semantic proximity Read ↗

S-phase checkpoint activity and function throughout the cell cycleSemantic proximity Read ↗

Regulation and roles of Cdc7 kinase under replication stressSemantic proximity Read ↗

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