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Article

Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries.

Circulation research - 19 Feb 2010

Watanabe Yusuke, Miyagawa-Tomita Sachiko, Vincent Stéphane D, Kelly Robert G, Moon Anne M, Buckingham Margaret E

Abstract excerpt

RATIONALE: The genes encoding fibroblast growth factor (FGF) 8 and 10 are expressed in the anterior part of the second heart field that constitutes a population of cardiac progenitor cells contributing to the arterial pole of the heart. Previous studies of hypomorphic and conditional Fgf8 mutants show disrupted outflow tract (OFT) and right ventricle (RV) development, whereas Fgf10 mutants do not have detectable...

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Share to Branchial Region
Share to Fetal Heart

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblast Growth Factor 10

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Share to Heart Defects, Congenital

Share to Heart Ventricles

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Source

Open in PubMed Open full text

Identifiers

PMID: 20035084
DOI: 10.1161/CIRCRESAHA.109.201665
PMCID: PMC2843098

Genes

FGF10
FGF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries.PMID 20035084Read ↗

Required, tissue-specific roles for Fgf8 in outflow tract formation and remodelingSemantic proximity Read ↗

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Tbx1 coordinates addition of posterior second heart field progenitor cells to the arterial and venous poles of the heart.Semantic proximity Read ↗

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Delta-like ligand-4 mediated Notch signaling controls proliferation of second heart field progenitor cells by regulating Fgf8 expressionSemantic proximity Read ↗

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