Article
Differential gene expression levels might explain association of LAIR2 polymorphisms with pemphigus.
Human genetics - 1 Feb 2016
Camargo Carolina Maciel, Augusto Danillo G, Petzl-Erler Maria Luiza
Abstract excerpt
The leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) is a collagen-binding inhibitory receptor important for the regulation of immune responses, expressed on the majority of peripheral blood mononuclear cells (PBMC). LAIR-2 is a soluble homolog that antagonizes LAIR-1 inhibitory function by binding the same ligands. We sought to investigate whether LAIR1 and LAIR2 single nucleotide polymorphisms (SNP)...
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