Article
Variation in genes implicated in B-cell development and antibody production affects susceptibility to pemphigus.
Immunology - 1 Jan 2021
Calonga-Solís Verónica, Amorim Leonardo M, Farias Ticiana D J, Petzl-Erler Maria Luiza, Malheiros Danielle, Augusto Danillo G
Abstract excerpt
Pemphigus foliaceus (PF) is an autoimmune blistering skin disease characterized by the presence of pathogenic autoantibodies against desmoglein 1, a component of intercellular desmosome junctions. PF occurs sporadically across the globe and is endemic in some Brazilian regions. Because PF is a B-cell-mediated disease, we aimed to study the impact of variants within genes encoding molecules involved in the...
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