Allelic and copy-number variations of FcγRs affect granulocyte function and susceptibility for autoimmune blistering diseases.

doi:10.1016/j.jaut.2015.05.004

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Article

Allelic and copy-number variations of FcγRs affect granulocyte function and susceptibility for autoimmune blistering diseases.

Journal of autoimmunity - 1 Jul 2015

Recke Andreas, Vidarsson Gestur, Ludwig Ralf J, Freitag Miriam, Möller Steffen, Vonthein Reinhard, Schellenberger Julia, Haase Ozan, Görg Siegfried, Nebel Almut, Flachsbart Friederike, Schreiber Stefan, Lieb Wolfgang, Gläser Regine, Benoit Sandrine, Sárdy Miklós, Eming Rüdiger, Hertl Michael, Zillikens Detlef, König Inke R, Schmidt Enno, Ibrahim Saleh

Abstract excerpt

Low-affinity Fcγ receptors (FcγR) bridge innate and adaptive immune responses. In many autoimmune diseases, these receptors act as key mediators of the pathogenic effects of autoantibodies. Genes encoding FcγR exhibit frequent variations in sequence and gene copy number that influence their functional properties. FcγR variations also affect the susceptibility to systemic autoimmunity, e.g. systemic lupus...

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PMID: 26032265
DOI: 10.1016/j.jaut.2015.05.004

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