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Article

Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake.

The Journal of biological chemistry - 26 Feb 2016

Nelson Jessica Kristine, Cook Emma Clare Laura, Loregger Anke, Hoeksema Marten Anne, Scheij Saskia, Kovacevic Igor, Hordijk Peter Lodewijk, Ovaa Huib, Zelcer Noam

Abstract excerpt

Cholesterol metabolism is subject to complex transcriptional and nontranscriptional regulation. Herein, the role of ubiquitylation is emerging as an important post-translational modification that regulates cholesterol synthesis and uptake. Similar to other post-translational modifications, ubiquitylation is reversible in a process dependent on activity of deubiquitylating enzymes (DUBs). Yet whether these play a...

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Topics

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Share to Human Umbilical Vein Endothelial Cells
Share to Lipoproteins, LDL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver X Receptors

Share to Lysosomes

Share to Orphan Nuclear Receptors

Share to Proteolysis

Share to Ubiquitin-Specific Proteases

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 26719329
DOI: 10.1074/jbc.M115.698688
PMCID: PMC4813502

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake.PMID 26719329Read ↗

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