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Article

Liver X receptor ligands suppress ubiquitination and degradation of LXRalpha by displacing BARD1/BRCA1.

Molecular endocrinology (Baltimore, Md.) - 1 Apr 2009

Kim Kang Ho, Yoon Jeong Min, Choi A Hyun, Kim Woo Sik, Lee Gha Young, Kim Jae Bum

Abstract excerpt

Liver X receptor (LXR) is a ligand-activated transcription factor that plays important roles in cholesterol and lipid homeostasis. However, ligand-induced posttranslational modification of LXR is largely unknown. Here, we show that ligand-free LXRalpha is rapidly degraded by ubiquitination. Witho...

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Source

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Identifiers

PMID: 19164445
DOI: 10.1210/me.2008-0295
PMCID: PMC5419272

Genes

BARD1
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19164445-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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