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Article

The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and Aβ amyloidosis.

Science translational medicine - 18 Nov 2015

Choi Jinkuk, Gao Jie, Kim Jaekwang, Hong Cynthia, Kim Jungsu, Tontonoz Peter

Abstract excerpt

Apolipoprotein E (ApoE) is an important modifier of Alzheimer's disease (AD) pathogenesis, and its abundance has been linked to the clearance of β-amyloid (Aβ) in the brain. The pathways that control the clearance of ApoE in the brain are incompletely understood. We report that Idol, an E3 ubiquitin ligase that targets the low-density lipoprotein receptor (LDLR) for degradation, is a critical determinant of brain...

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Share to Alzheimer Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Apolipoproteins E

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Share to Receptors, LDL

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Source

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Identifiers

PMID: 26582899
DOI: 10.1126/scitranslmed.aad1904
PMCID: PMC7153735

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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