Article
Role of β1 integrins and bacterial adhesins for Yop injection into leukocytes in Yersinia enterocolitica systemic mouse infection.
International journal of medical microbiology : IJMM - 1 Feb 2016
Deuschle Eva, Keller Birgit, Siegfried Alexandra, Manncke Birgit, Spaeth Tanja, Köberle Martin, Drechsler-Hake Doreen, Reber Julia, Böttcher Ralph T, Autenrieth Stella E, Autenrieth Ingo B, Bohn Erwin, Schütz Monika
Abstract excerpt
Injection of Yersinia outer proteins (Yops) into host cells by a type III secretion system is an important immune evasion mechanism of Yersinia enterocolitica (Ye). In this process Ye invasin (Inv) binds directly while Yersinia adhesin A (YadA) binds indirectly via extracellular matrix (ECM) proteins to β1 integrins on host cells. Although leukocytes turned out to be an important target of Yop injection by Ye, it...
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