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Article

Substitution of two histidine residues in YadA protein of Yersinia enterocolitica abrogates collagen binding, cell adherence and mouse virulence.

Molecular microbiology - 1 Jun 1995

Roggenkamp A, Neuberger H R, Flügel A, Schmoll T, Heesemann J

Abstract excerpt

The plasmid-encoded surface protein YadA of Yersinia enterocolitica mediates binding to diverse extracellular matrix (ECM) proteins, adherence to epithelial cell lines, resistance to complement lysis, autoagglutination, and is required for mouse virulence. Using site-directed mutagenesis we attempted to analyse the relationship between structural domains and functions of YadA. In a first approach we could...

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PMID: 8577254
DOI: 10.1111/j.1365-2958.1995.tb02343.x

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