Article
Yersinia pestis YopK Inhibits Bacterial Adhesion to Host Cells by Binding to the Extracellular Matrix Adaptor Protein Matrilin-2.
Infection and immunity - 1 Aug 2017
Tan Yafang, Liu Wanbing, Zhang Qingwen, Cao Shiyang, Zhao Haihong, Wang Tong, Qi Zhizhen, Han Yanping, Song Yajun, Wang Xiaoyi, Yang Ruifu, Du Zongmin
Abstract excerpt
Pathogenic yersiniae harbor a type III secretion system (T3SS) that injects Yersinia outer protein (Yop) into host cells. YopK has been shown to control Yop translocation and prevent inflammasome recognition of the T3SS by the innate immune system. Here, we demonstrate that YopK inhibits bacterial adherence to host cells by binding to the extracellular matrix adaptor protein matrilin-2 (MATN2). YopK binds to...
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